The thankless task of playing genetics with mammalian mitochondrial DNA:: a 30-year review

被引：7

作者：

Bayona-Bafaluy, MP ^{[1
]}

Fernández-Silva, P ^{[1
]}

Enríquez, JA ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain

来源：

MITOCHONDRION | 2002年 / 2卷 / 1-2期

关键词：

mtDNA mutation; mammalian cell; mutagenesis;

D O I：

10.1016/S1567-7249(02)00044-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The advances obtained through the genetic tools available in yeast for studying the oxidative phosphorylation (OXPHOS) biogenesis and in particular the role of the mtDNA encoded genes, strongly contrast with the very limited benefits that similar approaches have generated for the study of mammalian mtDNA. Here we review the use of the genetic manipulation in mammalian mtDNA, its difficulty and the main types of mutants accumulated in the past 30 years and the information derived from them. We also point out the need for a substantial improvement in this field in order to obtain new tools for functional genetic studies and for the generation of animal models of mtDNA-linked diseases. (C) 2002 Published by Elsevier Science B.V. and Mitochondria Research Society.

引用

页码：3 / 25

页数：23

共 202 条

[91] LACK OF ASSEMBLY OF MITOCHONDRIAL DNA-ENCODED SUBUNITS OF RESPIRATORY NADH DEHYDROGENASE AND LOSS OF ENZYME-ACTIVITY IN A HUMAN CELL MUTANT LACKING THE MITOCHONDRIAL ND4 GENE-PRODUCT [J].

HOFHAUS, G ;

ATTARDI, G .

EMBO JOURNAL, 1993, 12 (08) :3043-3048

[92]

HOFHAUS G, 1995, MOL CELL BIOL, V15, P3461

[93]

HOFHAUS G, 1994, EMBO J, V13, P5794

[94] DELETIONS OF MUSCLE MITOCHONDRIAL-DNA IN PATIENTS WITH MITOCHONDRIAL MYOPATHIES [J].

HOLT, IJ ;

HARDING, AE ;

MORGANHUGHES, JA .

NATURE, 1988, 331 (6158) :717-719

[95] Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: Segregation, maintenance and recombination dependent upon nuclear background [J].

Holt, IJ ;

Dunbar, DR ;

Jacobs, HT .

HUMAN MOLECULAR GENETICS, 1997, 6 (08) :1251-1260

[96] MITOCHONDRIAL CHLORAMPHENICOL-RESISTANT MUTANTS CAN HAVE DEFICIENCIES IN ENERGY-METABOLISM [J].

HOWELL, N ;

NALTY, MS .

SOMATIC CELL AND MOLECULAR GENETICS, 1988, 14 (02) :185-193

[97] SEQUENCE-ANALYSIS OF MITOCHONDRIAL CHLORAMPHENICOL RESISTANCE MUTATIONS IN CHINESE-HAMSTER CELLS [J].

HOWELL, N ;

KUBACKA, I .

MAMMALIAN GENOME, 1993, 4 (05) :271-275

[98] SEQUENCE-ANALYSIS OF MOUSE MITOCHONDRIAL CHLORAMPHENICOL-RESISTANT MUTANTS [J].

HOWELL, N ;

LEE, A .

SOMATIC CELL AND MOLECULAR GENETICS, 1989, 15 (03) :237-244

[99] ORIGIN, CELLULAR EXPRESSION, AND CYBRID TRANSMISSION OF MITOCHONDRIAL CAP-R, PYR-IND, AND OLI-R MUTANT PHENOTYPES [J].

HOWELL, N .

SOMATIC CELL GENETICS, 1983, 9 (01) :1-24

[100] CYTOPLASMIC GENETICS OF MAMMALIAN-CELLS - CONDITIONAL SENSITIVITY TO MITOCHONDRIAL INHIBITORS AND ISOLATION OF NEW MUTANT PHENOTYPES [J].

HOWELL, N ;

SAGER, R .

SOMATIC CELL GENETICS, 1979, 5 (06) :833-845

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