Fusion genes and prostate cancer. From discovery to prognosis and therapeutic perspectives

被引：8

作者：

Beuzeboc, P. ^{[1
]}

Soulie, M. ^{[2
]}

Richaud, P. ^{[3
]}

Salomon, L. ^{[4
]}

Staerman, F. ^{[5
]}

Peyromaure, M. ^{[6
]}

Mongiat-Artus, P. ^{[7
]}

Cornud, F. ^{[8
]}

Paparel, P.

Davin, J. -L. ^{[9
]}

Molinie, V. ^{[1
]}

机构：

[1] Inst Curie, Dept Med Oncol, F-75005 Paris, France

[2] CHU Toulouse, Serv Urol, Toulouse, France

[3] Inst Bergonie, Serv Radiotherapie, Bordeaux, France

[4] CHU Creteil, Serv Urol, Creteil, France

[5] CHU Reims, Serv Urol, Reims, France

[6] Hop Cochin, Serv Urol, F-75674 Paris, France

[7] Hop St Louis, Serv Urol, Paris, France

[8] IFR Lyon Est, Serv Urol, Lyon, France

[9] Hop St Joseph, Serv Anatomopathol, St Joseph, France

来源：

PROGRES EN UROLOGIE | 2009年 / 19卷 / 11期

关键词：

Prostate cancer; Fusion genes; TEMPSS2-ERG; TMPRSS2-ERG FUSION; OVEREXPRESSION; REARRANGEMENTS; TRANSCRIPTS; CARCINOMAS; EXPRESSION;

D O I：

10.1016/j.purol.2009.06.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

The identification of fusion genes provides new insights into the initial mechanisms of molecular events implicated in the prostate cancer tumorigenesis. The presence of TEMPRSS2-ETS fusion in up to half of all human prostate cancer makes it perhaps the most common genetic rearrangement in human epithelial tumors. Some data suggest that TMPRSS2-ERG fusion prostate cancers have a more aggressive phenotype, which may affect cancer progression and outcome in localized tumors treated with prostatectomy. This discovery should pave the way towards future targeted therapies. (C) 2009 Published by Elsevier Masson SAS.

引用

页码：819 / 824

页数：6

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