A chromosome-specific microdissected library increases marker density on bovine chromosome 1

被引：13

作者：

Sonstegard, TS ^{[1
]}

deLeon, FAP ^{[1
]}

Beattie, CW ^{[1
]}

Kappes, SM ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,DEPT VET & ANIM SCI,AMHERST,MA 01003

来源：

GENOME RESEARCH | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1101/gr.7.1.76

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic resolution of bovine chromosome 1 (BTA1) linkage group was significantly increased by screening for microsatellite clones in a microdissected library constructed from a bovine cell line carrying a t(1;29) translocation. Eighty-five percent of the microsatellites (ms) (46/54) identified were informative in the USDA/MARC mapping population, and 96% of these ms (44/46) linked to BTA1 (LOD > 3.0). When merged with 40 existing BTA1 markers the genetic map spanned 153.8 cM (sex-averaged interval, 1.9 cM). The fourfold improvement in marker density of BTA1 provides a genetic map that enhances mapping of quantitative trait loci and implementation of marker assisted selection.

引用

页码：76 / 80

页数：5

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