Cranial nerve modulation of human cortical swallowing motor pathways

被引:68
作者
Hamdy, S
Aziz, Q
Rothwell, JC
Hobson, A
Barlow, J
Thompson, DG
机构
[1] UNIV MANCHESTER, HOPE HOSP, DEPT GASTROENTEROL, SALFORD M6 8HD, LANCS, ENGLAND
[2] NEUROL INST, MRC, HUMAN MOVEMENT & BALANCE UNIT, LONDON WC1 3BG, ENGLAND
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1997年 / 272卷 / 04期
关键词
cerebral cortex; deglutition; electromyography; magnetic stimulation; esophagus; oropharynx;
D O I
10.1152/ajpgi.1997.272.4.G802
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Animal data indicate that cortical swallowing pathways can be modulated by cranial nerve afferent stimulation. We therefore studied the effects of human trigeminal and vagal nerve excitation on the corticofugal pathways to the oropharynx and esophagus, using electromagnetic stimulation. Unilateral stimulation of either the trigeminal or vagus nerve evoked two distinct reflex electromyographic responses in the pharynx and esophagus, an early response (latency range 19-30 ms) and a late response (latency range 42-72 ms). In the mylohyoid muscles, however, only a single response was seen (latency range 36-64 ms). Cortical stimulation also evoked electromyographic responses in the mylohyoid muscles, pharynx, and esophagus, with latencies of 8.5 +/- 0.3, 9.3 +/- 0.3, and 10.1 +/- 0.4 ms, respectively. When either trigeminal or vagus nerve stimulation preceded cortical stimulation, the cortically evoked responses were facilitated, with maximal effects at interstimulation intervals of 30-200 ms for pharynx and esophagus (P < 0.02) and at interstimulation intervals of 50-100 ms for mylohyoid muscles (P < 0.05). Our results demonstrate that stimulation of human cranial nerve afferent fibers facilitates cortical swallowing motor pathways.
引用
收藏
页码:G802 / G808
页数:7
相关论文
共 30 条
  • [1] Altman D. G., 1991, Practical statistics for medical research, P179
  • [2] AMASSIAN VE, 1991, ELECTROEN CLIN NEURO, P3
  • [3] AN OSCILLOGRAPHIC STUDY OF THE CENTRAL PATHWAYS OF THE VAGUS NERVE IN THE CAT
    ANDERSON, FD
    BERRY, CM
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1956, 106 (01) : 163 - 181
  • [4] MODULATION OF ESOPHAGEAL RESPONSES TO MAGNETIC STIMULATION OF THE HUMAN BRAIN BY SWALLOWING AND BY VAGAL-STIMULATION
    AZIZ, Q
    ROTHWELL, JC
    BARLOW, J
    THOMPSON, DG
    [J]. GASTROENTEROLOGY, 1995, 109 (05) : 1437 - 1445
  • [5] ESOPHAGEAL MYOELECTRIC RESPONSES TO MAGNETIC STIMULATION OF THE HUMAN CORTEX AND THE EXTRACRANIAL VAGUE NERVE
    AZIZ, Q
    ROTHWELL, JC
    BARLOW, J
    HOBSON, A
    ALANI, S
    BANCEWICZ, J
    THOMPSON, DG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1994, 267 (05): : G827 - G835
  • [6] EFFECTS OF VAGAL VOLLEYS AND SEROTONIN ON UNITS OF CINGULATE CORTEX IN MONKEYS
    BACHMAN, DS
    HALLOWITZ, RA
    MACLEAN, PD
    [J]. BRAIN RESEARCH, 1977, 130 (02) : 253 - 269
  • [7] SUPRABULBAR MODULATION OF REFLEX SWALLOWING
    BIEGER, D
    HOCKMAN, CH
    [J]. EXPERIMENTAL NEUROLOGY, 1976, 52 (02) : 311 - 324
  • [8] CAR A, 1973, J PHYSIOL-PARIS, V66, P553
  • [9] CAR A, 1975, EXP BRAIN RES, V22, P197
  • [10] EFFECTS OF VAGAL AFFERENT STIMULATION ON CERVICAL SPINOTHALAMIC TRACT NEURONS IN MONKEYS
    CHANDLER, MJ
    HOBBS, SF
    BOLSER, DC
    FOREMAN, RD
    [J]. PAIN, 1991, 44 (01) : 81 - 87