Multistep control of pituitary organogenesis

被引：295

作者：

Sheng, HZ

Moriyama, K

Yamashita, T

Li, H

Potter, SS

Mahon, KA

Westphal, H

机构：

[1] NICHHD,LAB MAMMALIAN GENES & DEV,NIH,BETHESDA,MD 20892

[2] SHIMANE MED UNIV,DEPT ANAT,IZUMO,SHIMANE 693,JAPAN

[3] ACAD SINICA,INST MOL BIOL,TAIPEI 11529,TAIWAN

[4] UNIV CINCINNATI,COLL MED,CHILDRENS HOSP RES FDN,CINCINNATI,OH 45229

[5] UNIV CINCINNATI,COLL MED,DEPT PEDIAT,CINCINNATI,OH 45229

[6] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

SCIENCE | 1997年 / 278卷 / 5344期

关键词：

D O I：

10.1126/science.278.5344.1809

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.

引用

页码：1809 / 1812

页数：4

共 17 条

[1] P-LIM, A LIM HOMEODOMAIN FACTOR, IS EXPRESSED DURING PITUITARY ORGAN AND CELL COMMITMENT AND SYNERGIZES WITH PIT-1 [J].