Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat

被引：38

作者：

Cobbs, CS

Fenoy, A

Bredt, DS

Noble, LJ

机构：

[1] SAN FRANCISCO GEN HOSP,DEPT NEUROSURG,SAN FRANCISCO,CA 94110

[2] UNIV CALIF SAN FRANCISCO,DEPT NEUROSURG,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

BRAIN RESEARCH | 1997年 / 751卷 / 02期

关键词：

traumatic brain injury; endothelial nitric oxide synthase; NADPHd;

D O I：

10.1016/S0006-8993(96)01429-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.

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页码：336 / 338

页数：3

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