Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women

被引：72

作者：

Gerdhem, Paul ^{[1
]}

Ivaska, Kaisa K.

Isaksson, Anders

Pettersson, Kim

Vaananen, H. Kalervo

Obrant, Karl J.

Akesson, Kristina

机构：

[1] Lund Univ, Malmo Univ Hosp, Dept Orthopaed, S-22100 Lund, Sweden

[2] Univ Turku, Dept Anat, Inst Biomed, SF-20500 Turku, Finland

[3] Univ Turku, Dept Biotechnol, SF-20500 Turku, Finland

[4] Lund Univ, Univ Lund Hosp, Dept Clin Biochem, S-22100 Lund, Sweden

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期

关键词：

aging; population studies; homocysteine; vitamin B-12 folate; BMD; bone ultrasound; bone metabolic markers; fracture; mortality;

D O I：

10.1359/JBMR.061003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from the OPRA study, high homocysteine level was associated with high bone marker levels and low BMD at baseline. During a mean 7-year follow-up, high homocysteine level was associated with mortality, but no clear association to fracture risk existed.

引用

页码：127 / 134

页数：8

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