Thioacetamide toxicity and the spleen: Histological and biochemical analysis

被引:21
作者
Al-Bader, A
Mathew, TC
Khoursheed, M
Asfar, S
Al-Sayer, H
Dashti, HM
机构
[1] Kuwait Univ, Fac Med, Dept Pathol, Hlth Sci Ctr, Safat 13110, Kuwait
[2] Kuwait Univ, Fac Med, Dept Pharmacol, Hlth Sci Ctr, Safat 13110, Kuwait
[3] Kuwait Univ, Fac Med, Dept Surg, Hlth Sci Ctr, Safat 13110, Kuwait
[4] Kuwait Univ, Fac Allied Hlth Sci & Nursing, Dept Med Lab Sci, Hlth Sci Ctr, Safat 13110, Kuwait
来源
ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C | 2000年 / 29卷 / 01期
关键词
D O I
10.1046/j.1439-0264.2000.00207.x
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Exposure to thioacetamide is associated with the development of liver cirrhosis in experimental animals. In addition to liver, thioacetamide toxicity has been observed in other organs. In this study, the toxic effect of thioacetamide on the spleen was investigated at 0, 4, 8 and 12 weeks post-treatment durations. The level of tissue copper and selenium increased until the eighth week when a significant drop was observed. The zinc level was also increased but returned back to normal by week 8, thereafter it showed further increase. Calculation of the copper/zinc ratio showed an increase, but, recovered and returned to normal value by week 12. The level of manganese fluctuated until the eighth week. It then increased rapidly. Histological studies of the spleen tissue showed a significant increase in extramedullary haematopoiesis in the red pulp region and marked hyperplasia in the marginal zone and follicles. The results of this study, demonstrate an intimate association between trace element levels and spleen pathology, as observed in studies of other organs.
引用
收藏
页码:3 / 8
页数:6
相关论文
共 21 条
[1]   Selenium and liver cirrhosis [J].
Al-Bader, A ;
Abul, H ;
Hussain, T ;
Al-Moosawi, M ;
Mathew, TC ;
Dashti, H .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 185 (1-2) :1-6
[2]  
Al-Bader AA, 1999, J TRACE ELEM EXP MED, V12, P1, DOI 10.1002/(SICI)1520-670X(1999)12:1<1::AID-JTRA1>3.0.CO
[3]  
2-L
[4]   HYPOCUPREMIA AND NEUTROPENIA IN COPPER DEFICIENCY [J].
CORDANO, A ;
PLACKO, RP ;
GRAHAM, GG .
BLOOD-THE JOURNAL OF HEMATOLOGY, 1966, 28 (02) :280-&
[5]  
Dashti H, 1995, J R Coll Surg Edinb, V40, P173
[6]   THIOACETAMIDE-INDUCED AND CARBON TETRACHLORIDE-INDUCED LIVER-CIRRHOSIS [J].
DASHTI, H ;
JEPPSSON, B ;
HAGERSTRAND, I ;
HULTBERG, B ;
SRINIVAS, U ;
ABDULLA, M ;
BENGMARK, S .
EUROPEAN SURGICAL RESEARCH, 1989, 21 (02) :83-91
[7]  
DASHTI H, 1986, PHARMACOL TOXICOL, V60, P171
[8]  
DASHTI H, 1992, SURG RES COMM, V12, P191
[9]  
Dashti HM, 1997, NUTRITION, V13, P206
[10]  
EJIMA A, 1992, LANCET, P339