Sex chromosomes and human growth - A dental approach

被引：89

作者：

Alvesalo, L

机构：

[1] University of Oulu, Institute of Dentistry, FIN-90220 Oulu

来源：

HUMAN GENETICS | 1997年 / 101卷 / 01期

基金：

芬兰科学院;

关键词：

D O I：

10.1007/s004390050575

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Studies on tooth crown size and structure of individuals with various sex chromosome anomalies and their normal male and female relatives have demonstrated differential direct effects on growth of genes on the human X and Y chromosomes. The Y chromosome promotes growth of both tooth enamel and dentin, whereas the effect of the X chromosome on tooth growth seems to be restricted to enamel formation. Enamel growth is decisively influenced by cell secretory function and dentin growth by cell proliferation. It is suggested that these differential effects of the X and Y chromosomes on growth explain the expression of sexual dimorphism in various somatic features, such as the size, shape and number of teeth, and, under the assumption of genetic pleiotropy, torus mandibularis, statural growth, and sex ratio. Future questions concern, among other topics, the Y chromosome and the mineralization process, concentric control of enamel and dentin growth, and gene expression.

引用

页码：1 / 5

页数：5

共 37 条

[1]

Alvesalo L, 1972, Proc Finn Dent Soc, V68, P307

[2] TOOTH SIZES IN 2 MALES WITH DELETIONS OF THE LONG ARM OF THE Y-CHROMOSOME [J].