REORGANIZATION OF THE CEREBRAL VASCULATURE FOLLOWING ISCHAEMIA

Introduction and development. Cerebral function needs a constant oxygen and glucose supply This is why the regulation of cerebral blood flow is critical for the maintenance of neuronal function. Therefore, vascular system in adult brain is extremely stable and does not withstand big changes under physiological conditions. However, when blood flow is interrupted clue to a focal cerebral ischemia the collateral tissue is partially affected, this is known as ischemic penumbra. Although its functionality is affected, this tissue is viable thanks to the collateral blood flow, and it releases angiogenic factors that induce proliferation of endothelial cells and migration of endothelial progenitor cells for the formation of new blood vessels. Angiogenesis induction and new vessel generation allow neurorepair processes, including neurogenesis and synaptogenesis. These two processes should be coupled with angiogenesis in order to contribute to functional recovery of patients who suffered a cerebral infarct. Therefore, angiogenesis could be one (if the therapeutic options in ischemic stroke treatment. Nevertheless, some angiogenic factors such as vascular endothelial growth factor, platelet derived growth factor and angiopoy also increase vascular permeability which can produce hemorrhagic transformation. Conclusions. Hence, the knowledge of molecular mechanisms that regulate angiogenesis after an ischemic stroke could contribute to the development of a new therapeutic option based on angiogenesis as a vehicle to promote neurorepair and functional recovery. [REV NEUROL 2009: 49: 645-54]