New method of sentinel node identification with ultrasonography using albumin as contrast agent: A study in pigs

被引:14
作者
Omoto, K [1 ]
Mizunuma, H
Ogura, S
Hozumi, Y
Nagai, H
Taniguchi, N
Itoh, K
机构
[1] Jichi Med Sch, Dept Clin Lab Med, Minamimaki, Tochigi 3290498, Japan
[2] Jichi Med Sch, Dept Surg, Minamimaki, Tochigi 3290498, Japan
关键词
ultrasonography; albumin; ultrasound contrast agent; subcutaneous injection; sentinel node; micrometastasis; animal model; lymphatic vessel;
D O I
10.1016/S0301-5629(02)00570-7
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
The purpose of our study was to verify in animals the possibility of using albumin-enhanced ultrasonography as a modality for sentinel node detection. The nine pigs were injected subcutaneously in the neck with albumin, five with 5% solution and four with 25% solution, and then the regional lymph nodes were observed over time. It was found that, where the 5% solution had been injected, the lymph nodes showed no change, but where the 25% solution had been used, a high echo, 1 to 5 mm in size was seen at the hilus of the nearest lymph node. Examination of the excised pathologic specimens of lymph nodes demonstrated that this echo was due to albumin accumulated in the efferent lymphatics. This finding suggested that this technique of ultrasonography using albumin as a contrast agent was an effective new method of identifying sentinel nodes. (C) 2002 World Federation for Ultrasound in Medicine Biology.
引用
收藏
页码:1115 / 1122
页数:8
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