Insulin receptor knock-out mice

被引：16

作者：

Accili, D

机构：

[1] Developmental Endocrinology Branch, Natl. Inst. Child Hlth. Hum. Devmt., National Institutes of Health, Bethesda

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1016/S1043-2760(97)00031-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Targeted mutagenesis of the insulin receptor gene in mice has yielded unexpected results. This article reviews recent findings and analyzes this animal model can further our understanding of the mechanism of insulin action and its impairment in non-insulin-dependent diabetes mellitus is analyzed.

引用

页码：101 / 104

页数：4

共 42 条

[1] MOLECULAR DEFECTS OF THE INSULIN-RECEPTOR GENE [J].

ACCILI, D .

DIABETES-METABOLISM REVIEWS, 1995, 11 (01) :47-62

[2] TARGETED INACTIVATION OF THE INSULIN-RECEPTOR GENE IN MOUSE 3T3-L1 FIBROBLASTS VIA HOMOLOGOUS RECOMBINATION [J].

ACCILI, D ;

TAYLOR, SI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4708-4712

[3] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene [J].

Accili, D ;

Drago, J ;

Lee, EJ ;

Johnson, MD ;

Cool, MH ;

Salvatore, P ;

Asico, LD ;

Jose, PA ;

Taylor, SI ;

Westphal, H .

NATURE GENETICS, 1996, 12 (01) :106-109

[4]

ACCILI D, 1994, MOL ENDOCRINOLOGY BA, P95

[5] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE [J].

ARAKI, E ;

LIPES, MA ;

PATTI, ME ;

BRUNING, JC ;

HAAG, B ;

JOHNSON, RS ;

KAHN, CR .

NATURE, 1994, 372 (6502) :186-190

[6]

BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O

[7] GLUCOSE KINETICS IN LEPRECHAUNISM - ACCELERATED FASTING DUE TO INSULIN RESISTANCE [J].

BIER, DM ;

SCHEDEWIE, H ;

LARNER, J ;

OLEFSKY, J ;

RUBENSTEIN, A ;

FISER, RH ;

CRAIG, JW ;

ELDERS, MJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 51 (05) :988-994

[8] FORMATION OF GERM-LINE CHIMERAS FROM EMBRYO-DERIVED TERATOCARCINOMA CELL-LINES [J].

BRADLEY, A ;

EVANS, M ;

KAUFMAN, MH ;

ROBERTSON, E .

NATURE, 1984, 309 (5965) :255-256

[9] Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles [J].

Bruning, JC ;

Winnay, J ;

BonnerWeir, S ;

Taylor, SI ;

Accili, D ;

Kahn, CR .

CELL, 1997, 88 (04) :561-572

[10] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

← 1 2 3 4 5 →