TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma

被引：38

作者：

Albadine, Roula

Latour, Mathieu

Toubaji, Antoun

Haffner, Michael ^{[3
]}

Isaacs, William B. ^{[2
,3
]}

Platz, Elizabeth A. ^{[3
,4
]}

Meeker, Alan K. ^{[2
]}

Demarzo, Angelo M. ^{[2
,3
]}

Epstein, Jonathan I. ^{[2
,3
]}

Netto, George J. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Med Inst, Johns Hopkins Hosp, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21231 USA

[3] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21231 USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

来源：

MODERN PATHOLOGY | 2009年 / 22卷 / 11期

关键词：

minute prostatic adenocarcinoma; TMPRSS2-ERG fusion; CANCER; RECURRENCE; FREQUENCY; VOLUME; FISH;

D O I：

10.1038/modpathol.2009.121

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Minute prostatic adenocarcinomas are considered to be of insufficient virulence. Given recent suggestions of TMPRSS2-ERG gene fusion association with aggressive prostatic adenocarcinoma, we evaluated the incidence of TMPRSS2-ERG fusion in minute prostatic adenocarcinomas. A total of 45 consecutive prostatectomies with minute adenocarcinoma were used for tissue microarray construction. A total of 63 consecutive non-minimal, Gleason Score 6 tumors, from a separate PSA Era prostatectomy tissue microarray, were used for comparison. FISH was carried out using ERG break-apart probes. Tumors were assessed for fusion by deletion (Edel) or split (Esplit), duplicated fusions and low-level copy number gain in normal ERG gene locus. Minute adenocarcinomas: Fusion was evaluable in 32/45 tumors (71%). Fifteen out of 32 (47%) tumors were positive for fusion. Six (19%) were of the Edel class and 7 (22%) were classified as combined Edel + Esplit. Non-minute adenocarcinomas (pT2): Fusion was identified in 20/30 tumors (67%). Four (13%) were of Edel class and 5 (17%) were combined Edel + Esplit. Duplicated fusions were encountered in 5 (16%) tumors. Non-minute adenocarcinomas (pT3): Fusion was identified in 19/33 (58%). Fusion was due to a deletion in 6 (18%) tumors. Seven tumors (21%) were classified as combined Edel + Esplit. One tumor showed Esplit alone. Duplicated fusions were encountered in 3 (9%) cases. The incidence of duplicated fusions was higher in non-minute adenocarcinomas (13 vs 0%; P = 0.03). A trend for higher incidence of low-level copy number gain in normal ERG gene locus without fusion was noted in non-minute adenocarcinomas (10 vs 0%; P = 0.07). We found a TMPRSS2-ERG fusion rate of 47% in minute adenocarcinomas. The latter is not significantly different from that of grade matched non-minute adenocarcinomas. The incidence of duplicated fusion was higher in non-minute adenocarcinomas. Our finding of comparable rate of TMPRSS2-ERG fusion in minute adenocarcinomas may argue against its value as a marker of aggressive prostate carcinoma phenotype. Modern Pathology (2009) 22, 1415-1422; doi: 10.1038/modpathol.2009.121; published online 4 September 2009

引用

页码：1415 / 1422

页数：8

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