Morphology and permeability of cellulose/chitin blend membranes

被引:58
作者
Liang, Songmiao
Zhang, Lina [1 ]
Xu, Han
机构
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
[2] Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100080, Peoples R China
基金
中国国家自然科学基金;
关键词
permeability; partition; cellulose; chitin; membrane;
D O I
10.1016/j.memsci.2006.10.002
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
A series of biodegradable cellulose/chitin blend membranes were successfully prepared from blend solution of cellulose and chitin in 9.5 wt% NaOH/4.5 wt% thiourea aqueous solution coagulating with 5.0 wt% (NH4)(2)SO4. The influence of chitin content on the morphology and structure of the membranes was studied by scanning electron microscopy, environmental scanning electron microscopy and wide-angle X-ray diffractometry, as well as Fourier transform infrared spectroscopy. Using double-cell method and solution depletion method, the permeability and partition coefficients of three model drugs (ceftazidine, cefazolin sodium, and thiourea) were determined in phosphate buffer solution to clarify the diffusion mechanism governing transport of solutes in these membranes. Diffusion coefficients were calculated from the permeability and partition coefficients in terms of Fick's law. The effects of the chitin content, pH, ionic strength, molecular size and temperature on the drug diffusion were also studied. Our results revealed that all of the membranes had a porous-like structure. The introduction of chitin exhibited great influence on the morphology and crystal structure of the blend membranes, resulting in a significant different permeability. For the first time, a dual diffusion mechanism with some hindrance of molecular diffusion via polymer obstruction was employed to explain the transport of drugs in the membranes. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:19 / 28
页数:10
相关论文
共 43 条
[1]   Comparison of protein fouling on heat-treated poly(vinyl alcohol), poly(ether sulfone) and regenerated cellulose membranes using diffuse reflectance infrared Fourier transform spectroscopy [J].
Amanda, A ;
Mallapragada, SK .
BIOTECHNOLOGY PROGRESS, 2001, 17 (05) :917-923
[2]   Solute diffusion within hydrogels. Mechanisms and models [J].
Amsden, B .
MACROMOLECULES, 1998, 31 (23) :8382-8395
[3]  
[Anonymous], 2001, SMART FIBERS FABRICS
[4]   Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol) [J].
Bell, CL ;
Peppas, NA .
BIOMATERIALS, 1996, 17 (12) :1203-1218
[5]   Phase diagram of a cellulose solvent:: N-methylmorpholine-N-oxide-water mixtures [J].
Biganska, O ;
Navard, P .
POLYMER, 2003, 44 (04) :1035-1039
[6]  
Brown W., 1965, EUR POLYM J, V1, P1, DOI [DOI 10.1016/0014-3057(65)90041-8, 10.1016/0014-3057(65)90041-8]
[7]   Rapid dissolution of cellulose in LiOH/Urea and NaOH/Urea aqueous solutions [J].
Cai, J ;
Zhang, L .
MACROMOLECULAR BIOSCIENCE, 2005, 5 (06) :539-548
[8]   HINDERED DIFFUSION OF WATER-SOLUBLE MACROMOLECULES IN MEMBRANES [J].
DAVIDSON, MG ;
DEEN, WM .
MACROMOLECULES, 1988, 21 (12) :3474-3481
[9]   Solution behavior of trimethylsilyl cellulose of different degrees of substitution, studied by static and dynamic light scattering [J].
Demeter, J ;
Mormann, W ;
Schmidt, J ;
Burchard, W .
MACROMOLECULES, 2003, 36 (14) :5297-5303
[10]   FTIR and FT-Raman studies of partially miscible poly(methyl methacrylate)/poly(4-vinylphenol) blends in solid states [J].
Dong, J ;
Ozaki, Y .
MACROMOLECULES, 1997, 30 (02) :286-292