Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS

被引：9

作者：

Manev, Hari ^{[1
]}

Manev, Radmila ^{[1
]}

机构：

[1] Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA

来源：

AMYOTROPHIC LATERAL SCLEROSIS | 2009年 / 10卷 / 5-6期

关键词：

Therapy; glutamate; neurophysiology; NEURONS; MICE;

D O I：

10.3109/17482960802702288

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite the beneficial effects of minocycline seen in animal models of ALS, initial clinical trials of minocycline in ALS patients failed to support its expected therapeutic usefulness. Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic.

引用

页码：416 / 417

页数：2

共 8 条

[1]

Carrì MT, 2008, LANCET NEUROL, V7, P118, DOI 10.1016/S1474-4422(08)70005-X

[2] Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca2+ signalling in hippocampal neurons [J].

Gonzalez, Jose Carlos ;

Egea, Javier ;

del Carmen Godino, Maria ;

Fernandez-Gomez, Francisco J. ;

Sanchez-Prieto, Jose ;

Gandia, Luis ;

Garcia, Antonio G. ;

Jordan, Joaquin ;

Hernandez-Guijo, Jesus M. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (09) :2481-2495

[3] A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS [J].

Gordon, Paul H. ;

Cheung, Ying-Kuen ;

Levin, Bruce ;

Andrews, Howard ;

Doorish, Carolyn ;

Macarthur, Robert B. ;

Montes, Jacqueline ;

Bednarz, Kate ;

Florence, Julaine ;

Rowin, Julie ;

Boylan, Kevin ;

Mozaffar, Tahseen ;

Tandan, Rup ;

Mitsumoto, Hiroshi ;

Kelvin, Elizabeth A. ;

Chapin, John ;

Bedlack, Richard ;

Rivner, Michael ;

Mccluskey, Leo F. ;

Pestronk, Alan ;

Graves, Michael ;

Sorenson, Eric J. ;

Barohn, Richard J. ;

Belsh, Jerry M. ;

Lou, Jau-Shin ;

Levine, Todd ;

Saperstein, David ;

Miller, Robert G. ;

Scelsa, Stephen N. .

AMYOTROPHIC LATERAL SCLEROSIS, 2008, 9 (04) :212-222

[4]

IMBESI M, 2008, NEUROSCI LETT

[5]

Leigh PN, 2008, LANCET NEUROL, V7, P119, DOI 10.1016/S1474-4422(08)70006-1

[6] Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice [J].

Mizoguchi, Hiroyuki ;

Takuma, Kazuhiro ;

Fukakusa, Ayumi ;

Ito, Yukio ;

Nakatani, Akiko ;

Ibi, Daisuke ;

Kim, Hyoung-Chun ;

Yamada, Kiyofumi .

PSYCHOPHARMACOLOGY, 2008, 196 (02) :233-241

[7] Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats [J].

Molina-Hernandez, Miguel ;

Patricia Tellez-Alcantara, Norma ;

Perez-Garcia, Julian ;

Ivan Olivera-Lopez, Jorge ;

Teresa Jaramillo-Jaimes, M. .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (07) :1660-1666

[8] Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity [J].

Zhao, Pingwei ;

Ignacio, Sheila ;

Beattie, Eric C. ;

Abood, Mary E. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (03) :572-579

← 1 →