Two new efficient preparations of enantiopure 2,2'-dihydroxy-6,6'-dimethoxy-1,1'-biphenyl

被引：20

作者：

Delogu, G

Fabbri, D

机构：

[1] C.N.R, Ist. Per l'Applic. Delle Tecniche C., Via Vienna 2

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(97)00021-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two new useful methods for the preparation of diol 1 starting from available compounds are described. Separation of the two enantiomers entails resolution of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallization followed by reduction afforded diol (aS)-1 and (aR)-1 in 100% and 72% ee, respectively. (C) 1997 Elsevier Science Ltd.

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页码：759 / 763

页数：5

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