Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus

被引：83

作者：

Zibert, A

Kraas, W

Meisel, H

Jung, G

Roggendorf, M

机构：

[1] UNIV TUBINGEN,INST ORGAN CHEM,D-7400 TUBINGEN,GERMANY

[2] UNIV KLINIKUM CHARITE,BERLIN,GERMANY

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 05期

关键词：

ENVELOPE GLYCOPROTEIN GP70; SINGLE-SOURCE OUTBREAK; SEQUENCE VARIABILITY; GENOME; CHIMPANZEES; ESCAPE; NEUTRALIZATION; REINFECTION; SELECTION; EMERGENCE;

D O I：

10.1128/JVI.71.5.4123-4127.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epitopes of hypervariable region 1 (HVR1) were mapped by enzyme-linked immunosorbent assay using follow-up sera of patients, all of whom were infected with the same isolate of hepatitis C virus (HCV). Our results suggest that (i) an early appearance (up to month 13 postinfection) of antibodies directed to the N terminus of HVR1 is associated with acute self-limiting infections of HCV and (ii) isolate-independent antibodies which are mainly directed to the C terminus of HVR1 seem to persist in chronically infected patients. The relevance of HVR1-specific antibodies for neutralization was evaluated by characterization of a rabbit serum.

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页码：4123 / 4127

页数：5

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