Hypertriglyceridemia: An Independent Risk Factor of Chronic Kidney Disease in Taiwanese Adults

Background: The prevalence and incidence of chronic kidney disease (CKD) are relatively high in Taiwanese patients than in patients of other Countries, particularly in the older age groups. Dyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial. With this regard, we evaluated the effects of hypertriglyceridemia oil renal function in Taiwanese adults (aged >= 40 years). Methods: Front January 2002 to December 2006, WC Conducted a community-based medical screening program in Chiayi County with 18,422 subjects (aged :40 years). The CKD was defined as all estimated glomerular Filtration rate of <60 mL min 1.73 m(2). Age, body mass index, systolic blood pressure, fasting plasma glucose, and serum total cholesterol were considered as potential confounders. Result: The CKD was prevalent in 24.2% of the middle-aged and elderly population. By using Multiple logistic regression models, we determined that old age and elevated levels of body mass index, systolic blood pressure, fasting plasma glucose, and cholesterol were associated with CKD. The adjusted odds ratios of CKD in participants with serum TG >= 200 mg/dL was 1.901 (95% confidence interval: 1.07-3.36; P < 0.05) and in participants with serum TG > 500 mg/dL it increased to 2.205 (1.33-3.64 P < 0.05). Conclusion: Hypertriglyceridemia is all independent risk factor for CKD ill Taiwanese adults. Thus, all effective screening program that identities people with hypertriglyceridemia is warranted.