Maternal HLA Class I Compatibility in Patients With Biliary Atresia

被引：14

作者：

Irie, Naoki ^{[1
]}

Muraji, Toshihiro ^{[2
]}

Hosaka, Naoki ^{[3
]}

Takada, Yasutsugu ^{[3
]}

Sakamoto, Seisuke ^{[4
]}

Tanaka, Kohichi ^{[5
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Anat & Dev Biol, Kyoto, Japan

[2] Ibaraki Childrens Hosp, Dept Surg, Mito, Ibaraki 3114145, Japan

[3] Kansai Med Univ, Dept Pathol, Kansai, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan

[5] Inst Biomed Res & Innovat, Kobe, Hyogo, Japan

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2009年 / 49卷 / 04期

关键词：

Biliary atresia; Graft-versus-host disease; Human leukocyte antigen; Maternal microchimerism; MICROCHIMERISM; FETUS;

D O I：

10.1097/MPG.0b013e31819a4e2c

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Biliary atresia (BA) is an inflammatory cholangiopathy of unknown etiology. Maternal microchimerism has been identified in the livers of patients with BA. We analyzed the human leukocyte antigen (HLA) compatibility between 57 BA patient-mother pairs and 50 control-mother pairs. The HLA class I matching was significantly more frequent in BA pairs (odds ratio [OR]=2.46) than controls. Similar results were also found in child-to-mother HLA compatibility (OR=2.16). Our results indicate that patients with BA have an immunogenetic histocompatible relationship with their mothers, which may result in an increase in maternal microchimerism found in BA. JPGN 49:488-492, 2009.

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收藏

页码：488 / 492

页数：5

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