Early clinical development of pharmaceuticals for type 2 diabetes mellitus: From preclinical models to human investigation

被引：7

作者：

Wagner, JA ^{[1
]}

机构：

[1] Merck Res Labs, Dept Clin Pharmacol, Rahway, NJ 07065 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2002年 / 87卷 / 12期

关键词：

D O I：

10.1210/jc.2002-020910

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：5362 / 5366

页数：5

共 48 条

[1]

Ahrén B, 2001, DIABETES, V50, pA104

[2] The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].

Berg, AH ;

Combs, TP ;

Du, XL ;

Brownlee, M ;

Scherer, PE .

NATURE MEDICINE, 2001, 7 (08) :947-953

[3] Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: Binding and activation correlate with antidiabetic actions in db/db mice [J].

Berger, J ;

Bailey, P ;

Biswas, C ;

Cullinan, CA ;

Doebber, TW ;

Hayes, NS ;

Saperstein, R ;

Smith, RG ;

Leibowitz, MD .

ENDOCRINOLOGY, 1996, 137 (10) :4189-4195

[4]

Berger Joel, 2002, Diabetes Technol Ther, V4, P163, DOI 10.1089/15209150260007381

[5]

Bush EN, 2001, DIABETES, V50, pA81

[6] Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones [J].

Chao, L ;

Marcus-Samuels, B ;

Mason, MM ;

Moitra, J ;

Vinson, C ;

Arioglu, E ;

Gavrilova, O ;

Reitman, ML .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (10) :1221-1228

[7]

COMBS TP, ENDOCRINOLOGY, V143, P998

[8] Glucagon antagonists for the treatment of Type 2 diabetes [J].

Connell, RD .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1999, 9 (06) :701-709

[9] Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30 [J].

Das, K ;

Lin, Y ;

Widen, E ;

Zhang, YH ;

Scherer, PE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (04) :1120-1129

[10]

DEFRONZO RA, 1992, DIABETES CARE, V15, P18

← 1 2 3 4 5 →