Ciliary signaling goes down the tubes

被引：19

作者：

Calvet, JP

机构：

[1] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Kidney Inst, Kansas City, KS 66160 USA

来源：

NATURE GENETICS | 2003年 / 33卷 / 02期

关键词：

D O I：

10.1038/ng1078

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The focus of research on polycystic kidney disease (PKD) has recently shifted to the primary cilia of renal epithelial cells. A new study shows that the protein products of the genes mutated in PKD mediate mechanosensory calcium mobilization, suggesting that a disruption of fluid-flow sensing triggers abnormal cell proliferation and cyst growth.

引用

页码：113 / 114

页数：2

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