Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses

被引：188

作者：

Applegate, Matthew B. ^{[1
]}

Partlow, Benjamin P. ^{[1
]}

Coburn, Jeannine ^{[1
]}

Marelli, Benedetto ^{[1
]}

Pirie, Christopher ^{[2
]}

Pineda, Roberto ^{[3
]}

Kaplan, David L. ^{[1
]}

Omenetto, Fiorenzo G. ^{[1
,4
]}

机构：

[1] Tufts Univ, Dept Biomed Engn, 4 Colby St, Medford, MA 02155 USA

[2] Tufts Univ, Cummings Sch Vet Med, 200 Westboro Rd, North Grafton, MA 01536 USA

[3] Harvard Univ, Sch Med, Dept Ophthalmol, 25 Shattuck St, Boston, MA 02115 USA

[4] Tufts Univ, Dept Phys, 4 Colby St, Medford, MA 02155 USA

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 12期

关键词：

TYROSINE; SCAFFOLDS;

D O I：

10.1002/adma.201504527

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography. [GRAPHICS] .

引用

页码：2417 / 2420

页数：4

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