Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro

被引：23

作者：

Labbauf, A ^{[1
]}

Klopman, G ^{[1
]}

Rosenkranz, HS ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 377卷 / 01期

关键词：

sister chromatic exchange; structure-activity; DNA reactivity; genotoxicity;

D O I：

10.1016/S0027-5107(97)00056-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structural analyses of the determinants associated with the induction of bone marrow sister chromatid exchanges in mice indicate that the phenomenon is based on an electrophilic attack on DNA. In that respect this phenomenon is different from the basis of the induction of SCE in cultured cells or of micronuclei in the bone marrow of rodents. The latter two phenomena involve other targets as well. Based on the recognition that the vast majority of recognized human carcinogens are genotoxic, the present finding indicates that the in vivo induction of SCE is a good biomarker, possibly even a biodosimeter, for exposure to potential carcinogens.

引用

页码：37 / 52

页数：16

共 67 条

[1] A SURVEY OF LYMPHOCYTE CHROMOSOMAL DAMAGE IN SLOVENIAN WORKERS EXPOSED TO OCCUPATIONAL CLASTOGENS [J].

ALSABTI, K ;

LLOYD, DC ;

EDWARDS, AA ;

STEGNAR, P .

MUTATION RESEARCH, 1992, 280 (03) :215-223

[2] CHEMICAL CARCINOGENESIS - TOO MANY RODENT CARCINOGENS [J].

AMES, BN ;

GOLD, LS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7772-7776

[3]

ANDERSEN ME, 1990, REG TOXICOL PHARM, V12, P2

[4]

ANDERSON BE, 1990, ENV MOL MUTAGEN S18, V16, P555

[5] AZATHIOPRINE, A CLASTOGEN IN HUMAN SOMATIC-CELLS - ANALYSIS OF CHROMOSOME-DAMAGE AND SCE IN LYMPHOCYTES AFTER EXPOSURE INVIVO AND INVITRO [J].

APELT, F ;

KOLINGERRESHEIM, J ;

BAUCHINGER, M .

MUTATION RESEARCH, 1981, 88 (01) :61-72

[6]

ARDITO G, 1980, MUTAT RES, V78, P208

[7] ACUTE AND LONG-TERM CYTOGENETIC EFFECTS OF TREATMENT IN CHILDHOOD-CANCER - SISTER-CHROMATID EXCHANGES AND CHROMOSOME-ABERRATIONS [J].

ARONSON, MM ;

MILLER, RC ;

HILL, RB ;

NICHOLS, WW ;

MEADOWS, AT .

MUTATION RESEARCH, 1982, 92 (1-2) :291-307

[8] CLASSIFICATION ACCORDING TO CHEMICAL-STRUCTURE, MUTAGENICITY TO SALMONELLA AND LEVEL OF CARCINOGENICITY OF A FURTHER 42 CHEMICALS TESTED FOR CARCINOGENICITY BY THE UNITED-STATES NATIONAL TOXICOLOGY PROGRAM [J].

ASHBY, J ;

TENNANT, RW ;

ZEIGER, E ;

STASIEWICZ, S .

MUTATION RESEARCH, 1989, 223 (02) :73-103

[9] WILL ALL CHEMICALS BE CARCINOGENIC TO RODENTS WHEN ADEQUATELY EVALUATED [J].

ASHBY, J ;

PURCHASE, IFH .

MUTAGENESIS, 1993, 8 (06) :489-493

[10] THE INFLUENCE OF CHEMICAL-STRUCTURE ON THE EXTENT AND SITES OF CARCINOGENESIS FOR 522 RODENT CARCINOGENS AND 55 DIFFERENT HUMAN CARCINOGEN EXPOSURES [J].

ASHBY, J ;

PATON, D .

MUTATION RESEARCH, 1993, 286 (01) :3-74

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