DNA REPLICATION Prime-time looping

被引：11

作者：

Dixon, Nicholas E. ^{[1
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

来源：

NATURE | 2009年 / 462卷 / 7275期

关键词：

D O I：

10.1038/462854a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this directional dilemma.

引用

页码：854 / 855

页数：2

共 4 条

[1] DNA primase acts as a molecular brake in DNA replication [J].

Lee, JB ;

Hite, RK ;

Hamdan, SM ;

Xie, XS ;

Richardson, CC ;

van Oijen, AM .

NATURE, 2006, 439 (7076) :621-624

[2] Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome [J].

Manosas, Maria ;

Spiering, Michelle M. ;

Zhuang, Zhihao ;

Benkovic, Stephen J. ;

Croquette, Vincent .

NATURE CHEMICAL BIOLOGY, 2009, 5 (12) :904-912

[3] Coordinating DNA replication by means of priming loop and differential synthesis rate [J].

Pandey, Manjula ;

Syed, Salman ;

Donmez, Ilker ;

Patel, Gayatri ;

Ha, Taekjip ;

Patel, Smita S. .

NATURE, 2009, 462 (7275) :940-U137

[4] Trading places on DNA-a three-point switch underlies primer handoff from primase to the replicative DNA polymerase [J].

Yuzhakov, A ;

Kelman, Z ;

O'Donnell, M .

CELL, 1999, 96 (01) :153-163

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