Evolutionary optimisation of enzymes

被引：35

作者：

Sutherland, JD ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(00)00087-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations of the effects of evolutionary optimisation at the structural level, through X-ray crystallography, reinforce the view that enzymes are best optimised by evolution and not by design.

引用

页码：263 / 269

页数：7

共 37 条

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