Regulatory mechanisms of AMPA receptors in synaptic plasticity

被引：696

作者：

Derkach, Victor A. ^{[1
]}

Oh, Michael C. ^{[1
]}

Guire, Eric S. ^{[1
]}

Soderling, Thomas R. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn2055

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously thought. This review focuses on recent evidence that alterations to AMPAR functional properties are coupled to their trafficking, cytoskeletal dynamics and local protein synthesis. These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling.

引用

页码：101 / 113

页数：13

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