Epigenetics and the Biological Definition of Gene x Environment Interactions

被引：650

作者：

Meaney, Michael J. ^{[1
]}

机构：

[1] McGill Univ, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada

来源：

CHILD DEVELOPMENT | 2010年 / 81卷 / 01期

关键词：

SEROTONIN TRANSPORTER GENE; CORTICOTROPIN-RELEASING-FACTOR; STRESSFUL LIFE EVENTS; CORTICOSTEROID RECEPTOR-BINDING; PITUITARY-ADRENAL FUNCTION; EARLY REARING ENVIRONMENT; MEDIAL PREFRONTAL CORTEX; MATERNAL-CARE; GLUCOCORTICOID-RECEPTOR; DNA METHYLATION;

D O I：

10.1111/j.1467-8624.2009.01381.x

中图分类号：

G44 [教育心理学];

学科分类号：

0402 ; 040202 ;

摘要：

Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.

引用

页码：41 / 79

页数：39

共 281 条

[1] Ecology - Phenotypic plasticity in the interactions and evolution of species [J].

Agrawal, AA .

SCIENCE, 2001, 294 (5541) :321-326

[2] Epigenetic Regulation in Human Brain-Focus on Histone Lysine Methylation [J].

Akbarian, Schahram ;

Huang, Hsien-Sung .

BIOLOGICAL PSYCHIATRY, 2009, 65 (03) :198-203

[3] Epigenetic transgenerational actions of endocrine disruptors and mate fertility [J].

Anway, MD ;

Cupp, AS ;

Uzumcu, M ;

Skinner, MK .

SCIENCE, 2005, 308 (5727) :1466-1469

[4] Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism [J].

Arbelle, S ;

Benjamin, J ;

Golin, M ;

Kremer, I ;

Belmaker, RH ;

Ebstein, RP .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (04) :671-676

[5] Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants [J].

Auerbach, J ;

Geller, V ;

Lezer, S ;

Shinwell, E ;

Belmaker, RH ;

Levine, J ;

Ebstein, RP .

MOLECULAR PSYCHIATRY, 1999, 4 (04) :369-373

[6] Maternal Effects as Generators of Evolutionary Change A Reassessment [J].

Badyaev, Alexander V. .

YEAR IN EVOLUTIONARY BIOLOGY 2008, 2008, 1133 :151-+

[7] Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus [J].

Bagot, Rosemary C. ;

van Hasselt, Felisa N. ;

Champagne, Danielle L. ;

Meaney, Michael J. ;

Krugers, Harm J. ;

Joels, Marian .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2009, 92 (03) :292-300

[8] Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial [J].

Bakermans-Kranenburg, Marian J. ;

Van IJzendoorn, Marinus H. ;

Pijlman, Fernke T. A. ;

Mesman, Judi ;

Juffer, Femmie .

DEVELOPMENTAL PSYCHOLOGY, 2008, 44 (01) :293-300

[9] CRF and CRF receptors: Role in stress responsivity and other behaviors [J].

Bale, TL ;

Vale, WW .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :525-557

[10] THE DYNAMICS OF PARENT OFFSPRING RELATIONSHIPS IN MAMMALS [J].

BATESON, P .

TRENDS IN ECOLOGY & EVOLUTION, 1994, 9 (10) :399-403

← 1 2 3 4 5 6 7 8 9 10 →