Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma

被引：50

作者：

Sole, F ^{[1
]}

Woessner, S ^{[1
]}

Florensa, L ^{[1
]}

Espinet, B ^{[1
]}

Mollejo, M ^{[1
]}

Martin, P ^{[1
]}

Piris, MA ^{[1
]}

机构：

[1] HOSP VIRGEN SALUD, SERV ANAT PATOL, TOLEDO, SPAIN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

cytogenetics; in situ hybridization; splenic marginal zone B-cell lymphoma;

D O I：

10.1046/j.1365-2141.1997.2163033.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have studied 19 cases of splenic marginal zone B-cell lymphoma (SMZBCL) combining cytological features, conventional cytogenetics, and in situ hybridization (ISH) techniques. A clonal chromosome abnormality was found in 11/19 patients (58%), The more frequent recurrent abnormalities were: del(3), del (7q), and involvement of chromosomes 1, 3, 7 and 8. No patient showed the translocation t(11;14)(q13;q32), An outstanding finding was the low incidence of trisomy 3 (36%) compared to patients with MALT lymphoma, These findings support the interpretation that SMZBCL is a distinct lymphoproliferative disorder.

引用

页码：446 / 449

页数：4

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