Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy

被引：362

作者：

Demircan, N.

Safran, B. G.

Soylu, M.

Ozcan, A. A. ^{[1
]}

Sizmaz, S.

机构：

[1] Cukurova Univ, Fac Med, Dept Ophthalmol, TR-01330 Adana, Turkey

[2] Numune Hosp, Dept Ophthalmol, Balcali, Turkey

来源：

EYE | 2006年 / 20卷 / 12期

关键词：

proliferative diabetic retinopathy; interleukin-1; beta; tumour necrosis factor-alpha; cytokines;

D O I：

10.1038/sj.eye.6702138

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

We measured interleukin- 1 beta (IL- 1 beta) and tumour necrosis factor- alpha (TNF-alpha) in the vitreous humour and serum of patients with proliferative diabetic retinopathy (PDR), in order to determine the role of these cytokines in the pathogenesis of the disease. Vitreous and serum samples were collected from 21 patients with PDR who were undergoing pars plana vitrectomy. Control vitreous samples were obtained from cadavers and control serum samples from healthy subjects. The cytokines were measured by enzyme-linked immunosorbent assay. Vitreous IL- 1 beta and TNF-alpha concentrations in patients with PDR exceeded those of controls (P < 0.05), as did serum IL- 1 beta and TNF-alpha. We suggest that increased vitreous IL- 1 beta and TNF-alpha levels may play a significant role in the pathogenesis of PDR, which features abnormal cell proliferation and neovascularisation.

引用

页码：1366 / 1369

页数：4

共 25 条

[1]

AKDUMAN L, 1994, RET VIT, V2, P279

[2]

AKSUNGER A, 1994, RET VIT, V2, P63

[3]

AREND WP, 1993, TXB RHEUMATOLOGY, V1, P227

[4]

INVIVO ANGIOGENIC ACTIVITY OF INTERLEUKINS [J].