Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

被引：826

作者：

Mora, J. Rodrigo

Iwata, Makoto

Eksteen, Bertus

Song, Si-Young

Junt, Tobias

Senman, Balimkiz

Otipoby, Kevin L.

Yokota, Aya

Takeuchi, Hajime

Ricciardi-Castagnoli, Paola

Rajewsky, Klaus

Adams, David H.

von Andrian, Ulrich H.

机构：

[1] Ctr Blood Res, Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci, Sanuki, Kagawa 7692193, Japan

[4] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[5] Univ Milano Bicocca, Dept Biosci & Biotechnol, Milan, Italy

来源：

SCIENCE | 2006年 / 314卷 / 5802期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1132742

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Normal intestinal mucosa contains abundant immunoglobulin A (IgA) - secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells ( DC) from GALT induce T cell - independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

引用

页码：1157 / 1160

页数：4

共 28 条

[1]

Cell surface recycling of internalized antigen permits dendritic cell priming of B cells [J].