Dietary iron deficiency decreases serum osteocalcin concentration and bone mineral density in rats

被引：69

作者：

Katsumata, Shin-ichi ^{[1
]}

Tsuboi, Rie ^{[1
]}

Uehara, Mariko ^{[1
]}

Suzuki, Kazuharu ^{[1
]}

机构：

[1] Tokyo Univ Agr, Dept Nutr Sci, Fac Appl Biosci, Setagaya Ku, Tokyo 1568502, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 10期

关键词：

dietary iron deficiency; osteocalcin; bone mineral density; rat;

D O I：

10.1271/bbb.60221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We investigated the effects of dietary iron deficiency on bone metabolism by measuring markers of bone turnover in rats. Twelve 3-week-old male Wistar-strain rats were fed a control diet or an iron-deficient diet for 4 weeks. Dietary iron deficiency decreased hemoglobin concentration and increased heart weight. Serum osteocalcin concentration, bone mineral content, bone mineral density, and mechanical strength of the femur were significantly lower in the iron-deficient group than in the control group. These results suggested that dietary iron deficiency affected bone, which might have been due to a decrease in bone formation in rats.

引用

页码：2547 / 2550

页数：4

共 16 条

[1]

BONDE M, 1994, CLIN CHEM, V40, P2022

[2]

BROWN JP, 1984, LANCET, V1, P1091

[3]

COMPARISON OF IMMUNO-ASSAYS AND HPLC-ASSAYS FOR THE MEASUREMENT OF URINARY COLLAGEN CROSS-LINKS [J].

CALABRESI, E ;

LASAGNI, L ;

FRANCESCHELLI, F ;

DELEONARDIS, V ;

BECORPI, A ;

SERIO, M ;

BRANDI, ML .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1994, 17 (08) :625-629

[4]

Chiba H., 1998, Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science, V51, P201

[5]

METABOLISM OF VITAMIN-D - CURRENT STATUS [J].

DELUCA, HF .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1976, 29 (11) :1258-1270

[6]

Dietary iron is associated with bone mineral density in healthy postmenopausal women [J].

Harris, MM ;

Houtkooper, LB ;

Stanford, VA ;

Parkhill, C ;

Weber, JL ;

Flint-Wagner, H ;

Weiss, L ;

Going, SB ;

Lohman, TG .

JOURNAL OF NUTRITION, 2003, 133 (11) :3598-3602

[7]

Dose-responsive alteration in hepatic lipid peroxidation and retinol metabolism with increasing dietary β-carotene in iron deficient rats [J].

Ikeda, R ;

Uehara, M ;

Takasaki, M ;

Chiba, H ;

Masuyama, R ;

Furusho, T ;

Suzuki, K .

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 2002, 72 (05) :321-328

[8]

Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy [J].

Maurer, J ;

Harris, MM ;

Stanford, VA ;

Lohman, TG ;

Cussler, E ;

Going, SB ;

Houtkooper, LB .

JOURNAL OF NUTRITION, 2005, 135 (04) :863-869

[9]

Bone morphology, strength and density are compromised in iron-deficient rats and exacerbated by calcium restriction [J].

Medeiros, DM ;

Plattner, A ;

Jennings, D ;

Stoecker, B .

JOURNAL OF NUTRITION, 2002, 132 (10) :3135-3141

[10]

Medeiros DM, 1997, J TRACE ELEM EXP MED, V10, P197

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