Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst

被引:79
作者
Chobotova, K
Spyropoulou, I
Carver, J
Manek, S
Heath, JK
Gullick, WJ
Barlow, DH
Sargent, IL
Mardon, HJ
机构
[1] Univ Oxford, John Radcliffe Hosp, Womens Ctr, Nuffield Dept Obstet & Gynaecol, Headington OX3 9DU, Oxford, England
[2] Univ Birmingham, Sch Biol Sci, Birmingham B15 2TT, W Midlands, England
[3] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England
基金
英国惠康基金;
关键词
heparin-binding epidermal growth factor; ErbB4; implantation;
D O I
10.1016/S0925-4773(02)00342-8
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro models for human implantation. Furthermore, we demonstrate specific localisation of the heparin-binding epidermal growth factor receptor ErbB4, on the surface of the trophectoderm in peri-implantation human blastocysts. Our data lead the way for further dissection of the molecular mechanisms of implantation of the human embryo, and have implications for infertility, in vitro fertilization and contraception. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:137 / 144
页数:8
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