Activated by Different Signals, the PhoP/PhoQ Two-Component System Differentially Regulates Metal Uptake
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作者:
Choi, Eunna
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Sungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South KoreaSungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South Korea
Choi, Eunna
[1
]
Groisman, Eduardo A.
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Washington Univ, Dept Mol Microbiol, Howard Hughes Med Inst, Sch Med, St Louis, MO 63110 USASungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South Korea
Groisman, Eduardo A.
[2
]
Shin, Dongwoo
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Sungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South KoreaSungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South Korea
Shin, Dongwoo
[1
]
机构:
[1] Sungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol Cell Biol, Sch Med, Suwon 440746, South Korea
[2] Washington Univ, Dept Mol Microbiol, Howard Hughes Med Inst, Sch Med, St Louis, MO 63110 USA
The PhoP/PhoQ two-component system controls several physiological and virulence functions in Salmonella enterica. This system is activated by low Mg2+, acidic pH, and antimicrobial peptides, but the biological consequences resulting from sensing multiple signals are presently unclear. Here, we report that the PhoP/PhoQ system regulates different Salmonella genes depending on whether the inducing signal is acidic pH or low Mg2+. When Salmonella experiences acidic pH, the PhoP/PhoQ system promotes Fe2+ uptake in a process that requires the response regulator RstA, activating transcription of the Fe2+ transporter gene feoB. In contrast, the PhoP-induced RstA protein did not promote feoB expression at neutral pH with low Mg2+. The PhoP/PhoQ system promotes the expression of the Mg2+ transporter mgtA gene only when activated in bacteria starved for Mg2+. This is because mgtA transcription promoted at high Mg2+ concentrations by the acidic-pH-activated PhoP protein failed to reach the mgtA coding region due to the mgtA leader region functioning as a Mg2+ sensor. Our results show that a single two-component regulatory system can regulate distinct sets of genes in response to different input signals.
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Chamnongpol, S
;
Groisman, EA
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Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Chamnongpol, S
;
Groisman, EA
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Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Cromie, MJ
;
Shi, YX
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Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Shi, YX
;
Latifi, T
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Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Latifi, T
;
Groisman, EA
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Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Chamnongpol, S
;
Groisman, EA
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机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Chamnongpol, S
;
Groisman, EA
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机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Cromie, MJ
;
Shi, YX
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机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Shi, YX
;
Latifi, T
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机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
Latifi, T
;
Groisman, EA
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机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA