Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics

被引：213

作者：

Ono, Shoichiro ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 258 | 2007年 / 258卷

关键词：

actin dynamics; gelsolin; ADF/cofilin; AIP1; cytoskeleton;

D O I：

10.1016/S0074-7696(07)58001-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The actin cytoskeleton is one of the major structural components of the cell. It often undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular processes, including cell migration, cytokinesis, membrane trafficking, and morphogenesis. Actin monomers are polymerized into filaments under physiological conditions, but spontaneous depolymerization is too slow to maintain the fast actin filament dynamics observed in vivo. Gelsolin, actin-depolymerizing factor (ADF)/cofilin, and several other actin-severing/ depolymerizing proteins can enhance disassembly of actin filaments and promote reorganization of the actin cytoskeleton. This review presents advances as well as a historical overview of studies on the biochemical activities and cellular functions of actin-severing/depolymerizing proteins.

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页码：1 / 82

页数：82

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