Serum (1-3)-β-D-Glucan as a Tool for Diagnosis of Pneumocystis jirovecii Pneumonia in Patients with Human Immunodeficiency Virus Infection or Hematological Malignancy

被引：82

作者：

Desmet, Stefanie

Van Wijngaerden, Eric ^{[2
]}

Maertens, Johan ^{[3
]}

Verhaegen, Jan

Verbeken, Eric ^{[4
]}

De Munter, Paul ^{[2
]}

Meersseman, Wouter ^{[2
]}

Van Meensel, Britt

Van Eldere, Johan

Lagrou, Katrien ^{[1
]}

机构：

[1] Katholieke Univ Leuven Hosp, Dienst Lab Umgeneeskunde, Dept Med Diagnost Sci, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven Hosp, Dept Gen Internal Med, B-3000 Louvain, Belgium

[3] Katholieke Univ Leuven Hosp, Dept Hematol, B-3000 Louvain, Belgium

[4] Katholieke Univ Leuven Hosp, Dept Pathol, B-3000 Louvain, Belgium

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 12期

关键词：

INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; ASSAY;

D O I：

10.1128/JCM.01756-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(1-3)-beta-D-Glucan (BG) reactivity was tested in serum samples from 28 patients with human immunodeficiency virus infection or a hematological malignancy and Pneumocystis jirovecii pneumonia (PCP) and 28 control patients. The sensitivity and specificity of BG detection with the Fungitell assay for PCP were 100 and 96.4%, respectively, using a cutoff value of 100 pg/ml. Serum BG testing looks promising for the noninvasive diagnosis of PCP. Our data suggest that a higher cutoff value for the diagnosis of PCP than for the diagnosis of invasive aspergillosis or candidiasis could be used safely and will improve the specificity of the test.

引用

收藏

页码：3871 / 3874

页数：4

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