The Treatment for Adolescents With Depression Study (TADS): Outcomes Over 1 Year of Naturalistic Follow-Up

被引：104

作者：

March, John

Silva, Susan

Curry, John

Wells, Karen

Fairbank, John

Burns, Barbara

Domino, Marisa

Vitiello, Benedetto

Severe, Joanne

Casat, Charles

Riedal, Karyn

Goldman, Marguerita

Feeny, Norah

Findling, Robert ^{[1
]}

Stull, Sheridan ^{[1
]}

Baab, Susan ^{[1
]}

Weller, Elizabeth B. ^{[2
]}

Robins, Michele ^{[2
]}

Weller, Ronald A. ^{[2
]}

Jessani, Naushad ^{[2
]}

Waslick, Bruce ^{[3
]}

Sweeney, Michael ^{[3
]}

Dublin, Randi ^{[3
]}

Walkup, John ^{[4
]}

Ginsburg, Golda ^{[4
]}

Kastelic, Elizabeth ^{[4
]}

Koo, Hyung ^{[4
]}

Kratochvil, Christopher ^{[5
]}

May, Diane ^{[5
]}

LaGrone, Randy ^{[5
]}

Vaughan, Brigette ^{[5
]}

Albano, Anne Marie ^{[6
]}

Hirsch, Glenn S. ^{[6
]}

Podniesinki, Elizabeth ^{[6
]}

Chu, Angela ^{[6
]}

Reinecke, Mark ^{[7
]}

Leventhal, Bennett ^{[7
]}

Rogers, Gregory ^{[7
]}

Jacobs, Rachel ^{[7
]}

Pathak, Sanjeev

Wells, Jennifer

Lavanier, Sarah A.

Danielyan, Arman

Rohde, Paul ^{[8
]}

Simons, Anne ^{[8
]}

Grimm, James ^{[8
]}

Frank, Stephenie ^{[8
]}

Emslie, Graham ^{[9
]}

Kennard, Beth ^{[9
]}

Hughes, Carroll ^{[9
]}

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Childrens Hosp Philadelphia, Philadelphia, PA USA

[3] Columbia Univ, New York, NY 10027 USA

[4] Johns Hopkins Univ, Baltimore, MD 21218 USA

[5] Univ Nebraska, Lincoln, NE 68583 USA

[6] NYU, New York, NY 10003 USA

[7] Northwestern Univ, Univ Chicago, Evanston, IL 60208 USA

[8] Univ Oregon, Eugene, OR 97403 USA

[9] Univ Texas SW Med Ctr Dallas, Dallas, TX USA

[10] Wayne State Univ, Detroit, MI 48202 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2009年 / 166卷 / 10期

关键词：

COGNITIVE-BEHAVIORAL THERAPY; MAJOR DEPRESSION; RELAPSE; TRIAL; PSYCHOTHERAPY; RECURRENCE; CHILDREN; PLACEBO; SAFETY; TIME;

D O I：

10.1176/appi.ajp.2009.08111620

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: The Treatment for Adolescents With Depression Study ( TADS) evaluates the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), and their combination in adolescents with major depressive disorder. The authors report effectiveness outcomes across a 1-year naturalistic follow-up period. Method: The randomized, controlled trial was conducted in 13 academic and community sites in the United States. Stages I, II, and III consisted of 12, 6, and 18 weeks of acute, consolidation, and continuation treatment, respectively. Following discontinuation of TADS treatments at the end of stage III, stage IV consisted of 1 year of naturalistic follow-up. The participants were 327 subjects between the ages of 12 and 17 with a primary DSM-IV diagnosis of major depressive disorder. No TADS treatment was provided during the follow-up period; treatment was available in the community. The primary dependent measures, rated by an independent evaluator blind to treatment status, were the total score on the Children's Depression Rating Scale-Revised and the rate of response, defined as a rating of much or very much improved on the Clinical Global Impressions improvement measure. Results: Sixty-six percent of the eligible subjects participated in at least one stage IV assessment. The benefits seen at the end of active treatment ( week 36) persisted during follow-up on all measures of depression and suicidality. Conclusions: In contrast to earlier reports on short-term treatments, in which worsening after treatment is the rule, the longer treatment in the TADS was associated with persistent benefits over 1 year of naturalistic follow-up.

引用

页码：1141 / 1149

页数：9

共 44 条

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