The neuropoietic cytokine family in development, plasticity, disease and injury

被引:299
作者
Bauer, Sylvian
Kerr, Bradley J.
Patterson, Paul H. [1 ]
机构
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] Univ Alberta, Dept Anesthesiol & Pain Med, Edmonton, AB, Canada
[3] Univ Aix Marseille 3, CNRS, UMR 6153, INRA 1147, F-13397 Marseille 20, France
关键词
D O I
10.1038/nrn2054
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuropoietic cytokines are well known for their role in the control of neuronal, glial and immune responses to injury or disease. Since this discovery, it has emerged that several of these proteins are also involved in nervous system development, in particular in the regulation of neurogenesis and stem cell fate. Recent data indicate that these proteins have yet more functions, as key modulators of synaptic plasticity and of various behaviours. In addition, neuropoietic cytokines might be a factor in the aetiology of psychiatric disorders.
引用
收藏
页码:221 / 232
页数:12
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