The in vitro activities of tigecycline and other antimicrobials against 51 isolates of Nocardia spp. were evaluated. MIC,os and MIC ranges were as follows: tigecycline, 4 and <= 0.06 to 8 mg/liter, respectively; minocycline, 2 and <= 0.06 to 2 mg/liter, respectively; linezolid, 1 and <= 0.06 to 2 mg/liter, respectively; moxifloxacin, 2 and <= 0.06 to > 64 mg/liter, respectively; ertapenem, 32 and <= 0.06-> 64 mg/liter, respectively; imipenem, 2 and <= 0.06 to > 64 mg/liter, respectively; meropenem, 8 and <= 0.06 to > 64 mg/liter, respectively; amikacin, 1 and <= 0.06 to 32 mg/liter, respectively; and trimethoprim-sulfamethoxazole, 1/19 and <= 0.5/9.5 to > 2/38 mg/liter, respectively.