Ambient level of NO2 augments the inflammatory response to inhaled allergen in asthmatics

被引:64
作者
Barck, C [1 ]
Sandström, T
Lundahl, J
Halldén, G
Svartengren, M
Strand, V
Rak, S
Bylin, G
机构
[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Div Resp Med & Allergol, S-14186 Stockholm, Sweden
[2] Univ Hosp No Sweden, Dept Resp Med & Allergy, Umea, Sweden
[3] Karolinska Hosp, Dept Clin Immunol, S-10401 Stockholm, Sweden
[4] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
[5] Sahlgrens Univ Hosp, Allergy Ctr, Gothenburg, Sweden
关键词
asthma; allergy; bronchial responsiveness; air pollution; nitrogen dioxide (NO2); lung function; inflammatory markers;
D O I
10.1053/rmed.2002.1374
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Air pollution constitutes an important factor for asthma aggravation, and there is increased concern about respiratory health effects of common air pollutants. The purpose of this study was to examine how exposure to a high ambient concentration nitrogen dioxide (NO2) prior to a bronchial allergen challenge modulated the inflammatory response in the bronchi. Thirteen subjects with mild asthma and allergy were exposed at rest to either purified air or 500 mug x m(-3) NO2 for 30 min, followed 4 h later by an allergen inhalation challenge. The exposures (NO2 or air) were performed in random order and at least 4 weeks apart. Lung function during NO2/air exposure and allergen challenge was measured by plethysmography, and then hourly by portable spirometry after exposures. Subjective symptoms were recorded during and after exposure. Bronchoscopy with bronchial wash (BW) and bronchoalveolar lavage (BAL) was performed 19 h after allergen challenge. NO2+allergen enhanced the percentage of neutrophils in both BW and BAL compared to air+allergen (BW 19 vs. 11, P=0.05; BAL 3 vs. I, P=0.02 median values). The levels of eosinophil cationic protein (ECP) in BW was higher after NO2+allergen compared to air+allergen (90 vs. 3.6 mug/l; P=0.02, median values). There was no NO2-associated effect on symptoms or pulmonary function. These data suggest that ambient NO2 can enhance allergic inflammatory reaction in the airways without causing symptoms or pulmonary dysfunction. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:907 / 917
页数:11
相关论文
共 30 条
[1]  
AALBERS R, 1993, EUR RESPIR J, V6, P840
[2]  
BAUER MA, 1986, AM REV RESPIR DIS, V134, P1203
[3]  
BERGLUND M, 1992, J EXPO ANAL ENV EPID, V2, P295
[4]  
BERGLUND M, 1993, SCAND J WORK ENV HEA, V19, P1
[5]   Persistent airway inflammation but accommodated antioxidant and lung function responses after repeated daily exposure to nitrogen dioxide [J].
Blomberg, A ;
Krishna, MT ;
Helleday, R ;
Söderberg, M ;
Ledin, MC ;
Kelly, FJ ;
Frew, AJ ;
Holgate, ST ;
Sandström, T .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (02) :536-543
[6]   The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects [J].
Blomberg, A ;
Krishna, MT ;
Bocchino, V ;
Biscione, GL ;
Shute, JK ;
Kelly, FJ ;
Frew, AJ ;
Holgate, ST ;
Sandstrom, T .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (02) :418-424
[7]  
BOSCIA J, 1998, AM J RESP CRIT CARE, V157, pA647
[8]   VARIABILITY IN AIRWAY CONDUCTANCE AND LUNG-VOLUME IN SUBJECTS WITH ASTHMA [J].
BYLIN, G ;
LAGERSTRAND, L ;
HEDENSTIERNA, G ;
WAGNER, PD .
CLINICAL PHYSIOLOGY, 1995, 15 (03) :207-218
[9]   NEW METHOD FOR MEASURING AIRWAY RESISTANCE IN MAN USING A BODY PLETHYSMOGRAPH - VALUES IN NORMAL SUBJECTS AND IN PATIENTS WITH RESPIRATORY DISEASE [J].
DUBOIS, AB ;
BOTELHO, SY ;
COMROE, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1956, 35 (03) :327-335
[10]   RAPID PLETHYSMOGRAPHIC METHOD FOR MEASURING THORACIC GAS VOLUME - COMPARISON WITH A NITROGEN WASHOUT METHOD FOR MEASURING FUNCTIONAL RESIDUAL CAPACITY IN NORMAL SUBJECTS [J].
DUBOIS, AB ;
BOTELHO, SY ;
BEDELL, GN ;
MARSHALL, R ;
COMROE, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1956, 35 (03) :322-326