Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: A possible mechanism of protection

被引:64
作者
Abd-Allah, ARA [1 ]
Al-Majed, AA [1 ]
Mostafa, AM [1 ]
Al-Shabanah, OA [1 ]
El Din, AG [1 ]
Nagi, MN [1 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh 11451, Saudi Arabia
关键词
arabic gum; creatine kinase; lipid peroxidation; cardiotoxicity; reduced glutathione; mice;
D O I
10.1002/jbt.10046
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Arabic gum (AG) is a naturally occurring compound that has been proposed to posses potent antioxidant activity. In this study, the possible effects whereby AG could protect against cardiotoxicity induced by doxorubicin (DOX) in mice were carried out. Administration of single dose of DOX (15 mg/kg, i.p.) induced cardiotoxicity 72 h, manifested biochemically by a significant elevation of serum creatine kinase (CK) (EC 2.7.3.2). In addition, cardiotoxicity was further confirmed by the significant increase in lipid peroxides measured as malondialdehyde (MDA). Administration of AG (25 g/kg) orally for 5 days before and 72 h after DOX injection produced a significant protection against cardiotoxicity induced by DOX. This was evidenced by significant reductions in serum CK and cardiac lipid peroxides. The effect of AG was examined on the superoxide anion radical generated by enzymatic and nonenzymatic methods. The results indicate that AG is a potent superoxide scavenger. The superoxide scavenging effect of AG may explain, at least in part, the protective effect of AG against cardiotoxicity induced by DOX. (C) 2002 Wiley Periodicals, Inc.
引用
收藏
页码:254 / 259
页数:6
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