Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones

被引:71
作者
Alagarsamy, V [1 ]
Salomon, VR [1 ]
Vanikavitha, G [1 ]
Paluchamy, V [1 ]
Chandran, MR [1 ]
Sujin, AA [1 ]
Thangathiruppathy, A [1 ]
Amuthalakshmi, S [1 ]
Revathi, R [1 ]
机构
[1] SB Coll Pharm, Med Chem Lab, Sivakasi 626130, Japan
关键词
quinazoline; analgesic; anti-inflammatory; thioureas; pyrimidine;
D O I
10.1248/bpb.25.1432
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.
引用
收藏
页码:1432 / 1435
页数:4
相关论文
共 10 条
  • [1] Alagarsamy V., 2000, Indian Journal of Pharmaceutical Sciences, V62, P63
  • [2] Alagarsamy V., 2000, Indian Journal of Pharmaceutical Sciences, V62, P433
  • [3] ALAGARSAMY V, 2003, IN PRESS FARMACO, V58
  • [4] Amour F. E., 1941, J PHARMACOL EXP THER, V72, P74
  • [5] Barry A., 1991, Antibiotics in Laboratory Medicine
  • [6] KOIZOMI M, 1917, JAPAN KOKAI, V77, P51
  • [8] Manabu H., 1990, CHEM PHARM BULL, V38, P618
  • [9] NIGAM R, 1990, INDIAN DRUGS, V27, P238
  • [10] WINTER CA, 1962, P SOC EXP BIOL MED, V111, P544