Glial cell responses to herpesvirus infections: Role in defense and immunopathogenesis

被引:60
作者
Lokensgard, JR
Cheeran, MCJ
Hu, SX
Gekker, G
Peterson, PK
机构
[1] Minneapolis Med Res Fdn Inc, Neuroimmunol Lab, Minneapolis, MN 55404 USA
[2] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
关键词
D O I
10.1086/344272
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Glial cells can respond to herpesvirus infections through the production of cytokines and chemokines. Although specific interactions between resident glia and lymphocytes that infiltrate the infected brain remain to be defined, the presence of T cell chemotactic signals in microglial cell supernatants following infection with cytomegalovirus or herpes simplex virus has led to the concept that chemokines initiate a cascade of neuroimmune responses that result in defense of the brain against herpesviruses. While chemokines may play a defensive role by attracting T cells into the brain, aberrant accumulation of lymphocytes may also induce brain damage. Host defense mechanisms must balance control of herpesvirus spread with associated undesirable immunopathologic effects. A growing body of evidence suggests that through complex networks of chemokines and cytokines produced in response to herpesvirus infection, glial cells orchestrate a cascade of events that result in successful defense of or damage to the brain.
引用
收藏
页码:S171 / S179
页数:9
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