Assembling of the four individual helices corresponding to the transmembrane segments (S4 in repeat I-IV) of the sodium channel

被引：21

作者：

Futaki, S

Aoki, M

Fukuda, M

Kondo, F

Niwa, M

Kitagawa, K

Nakaya, Y

机构：

[1] NIIGATA COLL PHARM,NIIGATA 95021,JAPAN

[2] UNIV TOKUSHIMA,SCH MED,TOKUSHIMA 770,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01651-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A template having four cysteines with selectively detachable protecting groups was developed, which enables selective introduction of individual helices by chemical ligation between the free sulfhydryl group on the template and the chloroacetyl moiety of the helical peptide. Using the template, a protein having ion channel activity with rectification was obtained. (C) 1997 Elsevier Science Ltd.

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收藏

页码：7071 / 7074

页数：4

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