Prognostic value of nodal ratios in node-positive breast cancer: a compiled update

被引：33

作者：

Vinh-Hung, Vincent

Nguyen, Nam P. ^{[3
]}

Cserni, Gabor ^{[4
]}

Truong, Pauline ^{[1
]}

Woodward, Wendy ^{[5
]}

Verkooijen, Helena M. ^{[6
]}

Promish, Donald

Ueno, Naoto T. ^{[7
]}

Tai, Patricia ^{[8
]}

Nieto, Yago

Joseph, Sue ^{[9
]}

Janni, Wolfgang ^{[10
]}

Vicini, Frank

Royce, Melanie

Storme, Guy ^{[11
]}

Wallace, Anne-Marie ^{[12
]}

Vlastos, Georges ^{[2
]}

Bouchardy, Christine ^{[13
]}

Hortobagyi, Gabriel N. ^{[14
]}

机构：

[1] British Columbia Canc Agcy, Vancouver Isl Ctr, INRWG, Dept Radiat Oncol, Victoria, BC V8R 6V5, Canada

[2] Univ Hosp Geneva, Dept Gynecol & Obstet, Div Gynecol, Senol & Surg Gynecol Oncol Unit, Geneva, Switzerland

[3] Univ Arizona, Tucson, AZ 85721 USA

[4] Bacs Kiskun Cty Hosp, Dept Pathol, Kecskemet, Hungary

[5] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA

[6] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore

[7] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Breast Canc Translat Res Lab, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX USA

[8] Allan Blair Canc Ctr, Saskatoon, SK, Canada

[9] Univ No Iowa, Cedar Falls, IA 50614 USA

[10] Klinikum Heinrich Heine Univ Dusseldorf, Frauenklin, Dusseldorf, Germany

[11] Oncol Ctr UZ Brussel, Dept Radiat Oncol, Brussels, Belgium

[12] Univ New Mexico, UNM Canc Res & Treatment Ctr, Albuquerque, NM 87131 USA

[13] Geneva Canc Registry, Geneva, Switzerland

[14] Univ Texas MD Anderson Canc Ctr, Dept Med Oncol, Houston, TX USA

来源：

FUTURE ONCOLOGY | 2009年 / 5卷 / 10期

关键词：

breast cancer; comparability; INRWG; International Nodal Ratio Working Group; lymph node; overdispersion; staging; SENTINEL-LYMPH-NODE; CIRCULATING TUMOR-CELLS; LOCOREGIONAL RECURRENCE RISK; BONE-MARROW; AXILLARY NODES; NEOADJUVANT CHEMOTHERAPY; CLINICAL-SIGNIFICANCE; PROSPECTIVE MULTICENTER; ADJUVANT RADIOTHERAPY; 1-3-POSITIVE NODES;

D O I：

10.2217/FON.09.129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The number of positive axillary nodes is a strong prognostic factor in breast cancer, but is affected by variability in nodal staging technique yielding varying numbers of excised nodes. The nodal ratio of positive to excised nodes is an alternative that could address this variability. Our 2006 review found that the nodal ratio consistently outperformed the number of positive nodes, providing strong arguments for the use of nodal ratios in breast cancer staging and management. New evidence has continued to accrue confirming the prognostic significance of nodal ratios in various worldwide population settings. This review provides an updated summary of available data, and discusses the potential application of the nodal ratio to breast cancer staging and prognostication, its role in the context of modern surgical techniques such as sentinel node biopsy, and its potential correlations with new biologic markers such as circulating tumor cells and breast cancer stem cells.

引用

页码：1585 / 1603

页数：19

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