Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

被引：84

作者：

Kim, Seung Hyun ^{[3
]}

Lee, Mi Kyeong ^{[4
]}

Lee, Ki Yong ^{[1
,2
]}

Sung, Sang Hyun ^{[1
,2
]}

Kim, Jinwoong ^{[1
,2
]}

Kim, Young Choong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[3] ElcomScience Co Ltd, Inst Life Sci, Seoul, South Korea

[4] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2009年 / 24卷 / 05期

关键词：

Paeonia lactiflora; monoterpenoid; neuroprotective; H2O2; primary cultures of rat cortical cells;

D O I：

10.1080/14756360802667977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.

引用

页码：1138 / 1140

页数：3

共 14 条

[1]

HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J].

BEHL, C ;

DAVIS, JB ;

LESLEY, R ;

SCHUBERT, D .

CELL, 1994, 77 (06) :817-827

[2]

Structural analysis of monoterpene glycosides extracted from Paeonia lactiflora Pall. using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry [J].

Dong, Hongjuan ;

Liu, Zhiqiang ;

Song, Fengrui ;

Yu, Zhan ;

Li, Huilin ;

Liu, Shuying .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (19) :3193-3199

[3]

HALLIWELL B, 1992, J LAB CLIN MED, V119, P598

[4]

PAEONILACTONE-A, PAEONILACTONE-B, AND PAEONILACTONE-C, NEW MONOTERPENOIDS FROM PAEONY ROOT [J].

HAYASHI, T ;

SHINBO, T ;

SHIMIZU, M ;

ARISAWA, M ;

MORITA, N ;

KIMURA, M ;

MATSUDA, S ;

KIKUCHI, T .

TETRAHEDRON LETTERS, 1985, 26 (31) :3699-3702

[5]

Jung BS, 1990, HYANG YAK DAE SA JEO, P523

[6]

Triterpenoids and flavonoids from Paeonia lactiflora [J].

Kamiya, K ;

Yoshioka, K ;

Saiki, Y ;

Ikuta, A ;

Satake, T .

PHYTOCHEMISTRY, 1997, 44 (01) :141-144

[7]

CHEMICAL STUDIES ON ORIENTAL PLANT DRUGS .33. ABSOLUTE STRUCTURES OF PAEONIFLORIN, ALBIFLORIN, OXYPAEONIFLORIN AND BENZOYLPAEONIFLORIN ISOLATED FROM CHINESE PEONY ROOT [J].

KANEDA, M ;

SHIBATA, S ;

IITAKA, Y .

TETRAHEDRON, 1972, 28 (16) :4309-+

[8]

Lee MK, 2000, J NEUROSCI RES, V59, P259, DOI 10.1002/(SICI)1097-4547(20000115)59:2<259::AID-JNR12>3.0.CO

[9]

2-3

[10]

Antioxidative constituents from Paeonia lactiflora [J].

Lee, SC ;

Kwon, YS ;

Son, KH ;

Kim, HP ;

Heo, MY .

ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (07) :775-783

← 1 2 →