Chiral multinuclear macrocyclic polyamine complexes: Synthesis, characterization and their interaction with plasmid DNA

被引：51

作者：

Fang, Yu-Guo

Zhang, Ji

Chen, Shan-Yong

Jiang, Ning

Lin, Hong-Hui

Zhang, Yu

Yu, Xiao-Qi

机构：

[1] Sichuan Univ, Dept Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan, Peoples R China

[2] Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China

[3] Sichuan Univ, State Key Lab Biotherapy, W China Hosp, W China Med Sch, Chengdu 610041, Sichuan, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

1,4,7,10-tetraazacyclododecane (cyclen); macrocyclic polyamine; multinuclear complexes; DNA cleavage; chemical nuclease;

D O I：

10.1016/j.bmc.2006.10.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of multinuclear macrocyclic polyantine metal (Zn2+, Cu2+, Co2+) complexes containing chiral dipeptide linkage were synthesized and used as artificial nuclease enzyme model. The interaction between the complexes and plasmid DNA (pUC19) was studied, and the results revealed that these complexes could act as powerful catalysts for the cleavage of plasmid DNA under physiological conditions. (c) 2006 Published by Elsevier Ltd.

引用

页码：696 / 701

页数：6

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