Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART

被引：30

作者：

Lehmann, Clara

Daeumer, Martin

Boussaad, Ibrahim

Sing, Tobias

Beerenwinkel, Niko

Lengauer, Thomas

Schmeisser, Norbert

Wyen, Christoph

Faetkenheuer, Gerd

Kaiser, Rolf

机构：

[1] Univ Cologne, Dept Internal Med, Cologne, Germany

[2] Univ Cologne, Inst Virol, Cologne, Germany

[3] Max Planck Inst Informat, Saarbrucken, Germany

[4] Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA

来源：

JOURNAL OF CLINICAL VIROLOGY | 2006年 / 37卷 / 04期

关键词：

HIV; chemokine receptors; virus tropism; HAART failure; resistance;

D O I：

10.1016/j.jcv.2006.08.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. Objectives: To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time. Methods: Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120. Results: Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching. Conclusions: Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option. ((c))2006 Elsevier B.V. All rights reserved.

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收藏

页码：300 / 304

页数：5

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