Light-induced release of DNA from plasmon-resonant nanoparticles: Towards light-controlled gene therapy

被引：108

作者：

Barhoumi, Aoune ^{[2
]}

Huschka, Ryan ^{[2
]}

Bardhan, Rizia ^{[2
]}

Knight, Mark W. ^{[1
]}

Halas, Naomi J. ^{[1
,2
,3
]}

机构：

[1] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA

[2] Rice Univ, Dept Chem, Houston, TX 77005 USA

[3] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

来源：

CHEMICAL PHYSICS LETTERS | 2009年 / 482卷 / 4-6期

关键词：

THERMAL-DENATURATION; MELTING TRANSITION; GOLD NANOPARTICLES; OPTICAL-PROPERTIES; DELIVERY; NANOSTRUCTURES; PARAMETERS; STABILITY; HEAT; OLIGONUCLEOTIDES;

D O I：

10.1016/j.cplett.2009.09.076

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Surface-plasmon driven DNA dehybridization is a topic of intense current interest due to its highly promising potential for enabling light-controlled gene therapy: it is also of inherent interest as a light-driven nanoscale actuation process. In this study we formulate an Au nanoshell-based complex designed to release single-stranded DNA (ssDNA) from its surface when illuminated with plasmon-resonant light. This system allows us to examine DNA dehybridization induced by excitation of localized surface plasmons on the nanoparticle, relative to the thermal DNA dehybridization (melting). The dehybridization temperatures, and the percentage of DNA released per nanoparticle, differ markedly between the two processes. (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：171 / 179

页数：9

共 67 条

[1] Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates [J].