The making of Wnt: new insights into Wnt maturation, sorting and secretion

被引:94
作者
Coudreuse, Damien
Korswagen, Hendrik C.
机构
[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands
[2] Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands
来源
DEVELOPMENT | 2007年 / 134卷 / 01期
关键词
D O I
10.1242/dev.02699
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this review, we look at the processes that occur 'behind the scenes' in Wnt signalling, within the Wnt-producing cells. The Wnt community has long been focused upon events that occur downstream of Wnt binding to its receptors, but the recent discovery that the maturation of the Wnt protein may have a profound effect on its signalling properties has excited great interest. In the last 2 years, several key regulators of Wnt production have been discovered, but our global understanding of this process remains relatively poor. Several models that reconcile former and recent observations of Wnt modification, sorting and secretion, and which highlight the potential of this emerging field, are presented here.
引用
收藏
页码:3 / 12
页数:10
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