Spectrum of Bacille Calmette-Guerin (BCG) infection after intravesical BCG immunotherapy

被引:134
作者
Gonzalez, OY
Musher, DM
Brar, I
Furgeson, S
Boktour, MR
Septimus, EJ
Hamill, RJ
Graviss, EA
机构
[1] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Infect Dis Sect, Houston, TX 77030 USA
[3] Vet Affairs Med Ctr, Houston, TX 77030 USA
[4] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
[5] Univ Texas, Hlth Sci Ctr, Houston, TX USA
[6] Memorial Hermann Hlth Care Syst, Houston, TX USA
[7] Henry Ford Hosp, Detroit, MI USA
关键词
D O I
10.1086/344908
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Intravesical instillation of bacille Calmette-Guerin (BCG) effectively treats transitional cell carcinoma of the bladder. Occasionally, BCG infection complicates such treatment. In some patients, infection appears early (within 3 months after instillation) and is characterized by generalized symptoms, with pneumonitis and hepatitis. Late-presentation disease occurs >1 year after the first BCG treatment and usually involves focal infection of the genitourinary tract (the site at which bacteria were introduced) and/or other sites that are typical for reactivation of mycobacterial disease, such as the vertebral spine or the retroperitoneal tissues. Noncaseating granulomas are found in the majority of cases, whether early or late. Most patients respond to treatment with antituberculous drugs; in early-presentation disease, when features of hypersensitivity predominate, glucocorticosteroids are sometimes added. Late localized infection often requires surgical resection.
引用
收藏
页码:140 / 148
页数:9
相关论文
共 50 条
[1]   AUTOCRINE REGULATION OF ICAM-1 EXPRESSION ON BLADDER-CANCER CELL-LINES - EVIDENCE FOR THE ROLE OF IL-1-ALPHA [J].
ALEXANDROFF, AB ;
JACKSON, AM ;
ESUVARANATHAN, K ;
PRESCOTT, S ;
JAMES, K .
IMMUNOLOGY LETTERS, 1994, 40 (02) :117-124
[2]   Mycobacterium bovis BCG causing vertebral osteomyelitis (Pott's disease) following intravesical BCG therapy [J].
Aljada, IS ;
Crane, JK ;
Corriere, N ;
Wagle, DG ;
Amsterdam, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (06) :2106-2108
[3]   COMPLICATIONS AFTER INTRAVESICAL INSTILLATION OF BACILLUS CALMETTE-GUERIN - RHABDOMYOLYSIS AND METASTATIC INFECTION [J].
ARMSTRONG, RW .
JOURNAL OF UROLOGY, 1991, 145 (06) :1264-1266
[4]  
ARZT MR, 1995, ANN CLIN LAB SCI, V25, P409
[5]   A 57-year-old man with fever and jaundice after intravesical instillation of bacille Calmette-Guerin for bladder cancer - Granulomatous hepatitis due to intravesical instillation of BCG for urinary bladder carcinoma [J].
Barza, MJ ;
Blum, JH ;
Graeme-Cook, FM ;
Basgoz, N .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (12) :831-837
[6]   INTERNALIZATION OF BACILLE CALMETTE-GUERIN BY BLADDER-TUMOR CELLS [J].
BECICH, MJ ;
CARROLL, S ;
RATLIFF, TL .
JOURNAL OF UROLOGY, 1991, 145 (06) :1316-1324
[7]   EFFECTS OF LOCAL BACILLUS CALMETTE-GUERIN THERAPY IN PATIENTS WITH BLADDER-CARCINOMA ON IMMUNOCOMPETENT CELLS OF THE BLADDER WALL [J].
BOHLE, A ;
GERDES, J ;
ULMER, AJ ;
HOFSTETTER, AG ;
FLAD, HD .
JOURNAL OF UROLOGY, 1990, 144 (01) :53-58
[8]   In vitro generation of bacillus Calmette-Guerin-activated killer cells [J].
Brandau, S ;
Böhle, A ;
Thanhäuser, A ;
Ernst, M ;
Mattern, T ;
Ulmer, AJ ;
Flad, HD .
CLINICAL INFECTIOUS DISEASES, 2000, 31 :S94-S100
[9]  
Casanova JL, 1996, PEDIATRICS, V98, P774
[10]   Idiopathic disseminated BCG or non-tuberculous mycobacteria infections. [J].
Casanova, JL .
ARCHIVES DE PEDIATRIE, 1997, 4 (09) :883-885